Screening Resorufin Pentyl Ether Analogs for Enhanced Antimicrobial Activity Against Francisella tularensis and Neisseria gonorrhoeae

Antibiotic resistance is an urgent public health threat. The CDC estimates there are approximately 2.8 million new cases of antibiotic-resistant infections annually resulting in 35,000 deaths and billions dollars care costs. development drugs imperative to combat this crisis prevent the loss additional lives from once “curable” diseases. Resazomycins, a novel family antibiotics, have bactericidal activity against Francisella tularensis Neisseria gonorrhoeae. One resazomycin, resorufin pentyl ether (RPE), significantly reduces vaginal colonization by N. gonorrhoeae mouse model infection. Repeated administration RPE, however, fails clear infection, contrast single dose ceftriaxone, antibiotic commonly used treat gonorrhea, which clears infection within 24 hours. Further characterization resazomycins revealed efficacy these compounds limited interaction with serum albumin reduced oxygen concentrations found mammalian tissues. Therefore, we hypothesize that resazurin analogs maintain antimicrobial presence low will improved therapeutic vivo. To date, two different derivatives RPE been synthesized tested for F. – 1-methyl 4-methyl RPE. Neither inhibited growth or Next, plan prepare series ketone alter electrophilicity reduction potential test their